Simple, low-cost measures go a long way in protecting both the client and health care worker from infection. Examples are proper hand washing, safe handling of “sharps,” and use of personal protective equipment. By systematically integrating such infection prevention practices with all health care services, facilities and countries may control and reduce the spread of infectious diseases, promote the use of effective waste management, minimize environmental pollution and reduce the perceived risk of HIV infection for health care providers. Changing perceptions about this risk is essential to building and maintaining an adequate health workforce. Materials here contain up-to-date, evidence-based guidance on comprehensive infection prevention and control approaches and integrating them with health care services.